Vincenza
Barresi., Ph.D.
Born
in Palmi (RC) March,31 1967. Italian. Married, one children.
Section
of Medical Biochemistry, Department of Biomedical and Biotechnological
Sciences,
University of Catania - Torre
Biologica, Torre Est, Piano IV
Via Santa Sofia n. 89-97, 95123 CATANIA
- Italy
tel.: +39 095 4781155, barregi@unict.it, skype: vincenzabarresi
Professional
position: Associate professor of
Clinical Biochemistry and Clinical Molecular Biology, Faculty of Medicine, University of Catania from 2006-to date.
Degrees:
Biological Sciences: University of Catania (Italy), March, 11, 1991 (110/110 cum laude).
Ph.D.
in Neurobiology: University of Catania (Italy), 1991-1994.
Research
training abroad: 1994-1995: at the Neurobiochemistry Group of the Mental
Retardation Center, UCLA, Los Angeles (Dir.: Prof J. De Vellis)
Specialist
in Clinical Biochemistry: University of Catania, November, 30, 1998 (cum
laude).
Component
Joint Committee, School Faculty of Medicine, University of Catania November
2016-October 2020)
-
Analysis of neurotransmitter receptors in glial cells
(metabotropic and ionotropic glutamate receptors): gene expression and second
messenger pathways
-
Structure and expression of the
glial fibrillary acidic gene (GFAP, GenBank accession number Z48978 e
AF028784);
-
Structure and expression of the Homo sapiens Rho GTPase activating
protein 26 variant 3 (ARHGAP26) mRNA, partial cds, alternatively spliced
(ARHGAP26, GenBank accession number HM037040.1)
- Transplantation of
prodrug-converting neural progenitor cells for brain tumor therapy
- Structure
and expression of connexins in the
nervous system and in skeletal muscle differentiation and regeneration.
- Application
of multivariate statistical analysis to cDNA microarray data.
- Antiproliferative
effects of new synthesis organic molecules and compounds extract from
agroindustrial wastes.
- Identification
of genes involved in the sensitivity to new drugs for the treatment of tumors
and knocking-down of these specific
transcripts by the RNA interference methodology
- Identification
of putative membrane receptors that could play a role in the cell death and
proliferation of cerebral tumors.
- Single
nucleotide polymorphism (SNP) analysis in case-control association studies.
- Application of high-resolution
SNP-arrays to determine novel molecular tumor-associated abnormalities genetic
alterations including tumor-associated copy number abnormalities (CNAs) and
copy neutral loss of heterozygosity (CN-LOH) regions and identification of possible recurring genomic abnormalities. Raw
and processed data of SNP 6.0-array and expression array results have been submitted to public
repository: ‘‘Gene Expression Omnibus-GEO’’ (www.ncbi.
nlm.nih.gov/geo) with the following accession number:
1- GenBanK
con accession number GSE22028,
2- Genbank con
accession number GSE21780,
3 -GenBank con
accession number GSM547642, Platform GPL10464 -Incyte Genomics Human UniGene 1
9.1K Microarray).
-
Application of Human Transcriptome Array (HTA 2.0) to analyse the levels of entire repertoire of cellular
mRNAs and a large number of non-coding RNAs in colorectal
cancer and corresponding mucosae. The data have been deposited to public
repository: “Gene Expression Omnibus-GEO” (www.ncbi.nlm.nih.gov/geo) with the
following accession number:GSE73360.
Scientific publications.
She is author of 54
scientific original papers published in international peer-reviewed journals,
12 scientific original papers published in national peer-reviewed journals, 3
chapters in books and 95 abstracts.
Selected scientific publications from 2010-to date:
1. Barresi, V.,
Bonaccorso, C., Cristaldi, D.A.
, Modica, M.N., Musso, N.,
Pittalà, V., Salerno, L., Fortuna, C.G. Synthesis and experimental validation of new designed heterocyclic
compounds with antiproliferative activity versus breast cancer cell lines MCF-7
and MDA-MB-231. Journal of Chemistry 2017, Article number 9729284
2. V. Barresi, S. Castorina, N. Musso, C.
Capizzi, T. Luca, G. Privitera, D.F. Condorelli. Chromosomal instability analysis and
regional tumor heterogeneity in colon cancer" Cancer Genetics V.210, 1
January 2017, Pages 9-21
3. Sonia Pedotti,
Martina Ussia, Angela Patti, Nicolò Musso, Vincenza
Barresi, Daniele F Condorelli,
Synthesis of the ferrocenyl analogue of clotrimazole drug. Journal of Organometallic Chemistry, Vol 830, 15
February 2017, Pages 56-61.
4. Barresi V, Trovato-Salinaro A, Spampinato
G, Musso N, Castorina S, Rizzarelli E, Condorelli DF. Transcriptome analysis of copper homeostasis genes reveals coordinated
upregulation of SLC31A1, SCO1, and COX11 in colorectal cancer. FEBS Open Bio.
2016 Jul 8;6(8):794-806
5. A Accardo, L. Del Zoppo, G Morelli, D. F.
Condorelli, V. Barresi, N. Musso, G.
Spampinato, F. Bellia, G. Tabbì and E. Rizzarelli Liposome antibody–ionophore
conjugate antiproliferative activity increases by cellular metallostasis
alteration (Royal Society of Chemistry) September 29.2016.
DOI:10.1039/C6MD00461.J. /MedChemComm/, 2016, 7, 2364 – 2367
6.
Cardullo N, Pulvirenti L, Spatafora C, Musso N, Barresi V, Condorelli DF, Tringali C.
Dihydrobenzofuran Neolignanamides: Laccase-Mediated Biomimetic Synthesis and
Antiproliferative Activity. J Nat Prod. 2016 Aug 26;79(8):2122-34. doi:
10.1021/acs.jnatprod.6b00577.
7. Barresi V, Spampinato G, Musso N,
Trovato Salinaro A, Rizzarelli E, Condorelli DF. ATOX1 gene silencing increases susceptibility to anticancer therapy
based on copper ionophores or chelating drugs. J Inorg Biochem. 2016 Jan
11;156:145-152.
8. Cardullo N, Spatafora C, Musso N, Barresi V, Condorelli D, Tringali C.
Resveratrol-Related Polymethoxystilbene Glycosides: Synthesis,
Antiproliferative. Activity, and Glycosidase Inhibition. J Nat Prod.
2015 Nov 25;78(11):2675-83.
9. Musso N,
Caronia FP, Castorina S, Lo Monte AI, Barresi
V, Condorelli DF. Somatic
loss of an EXT2 gene mutation during malignant progression in a patient with
hereditary multiple osteochondromas. Cancer Genet. 2015 Mar;208(3):62-7.
10. Privitera G, Luca T, Musso N, Vancheri C, Crimi N, Barresi V, Condorelli D, Castorina S.
In vitro antiproliferative effect of trastuzumab (Herceptin(®)) combined with
cetuximab (Erbitux (®)) in a model of human non-small cell lung cancer
expressing EGFR and HER2. Clin Exp Med. 2015 Feb 26.
11. Luca T, Barresi
V, Privitera G, Musso N, Caruso M, Condorelli DF, Castorina S. In vitro
combined treatment with cetuximab and trastuzumab inhibits growth of colon
cancer cells. Cell Prolif. 2014 Oct;47(5):435-47.
12. Barresi V, Signorelli SS, Musso N,
Anzaldi M, Fiore V, Alberghina M, Condorelli DF. ICAM-1 and SRD5A1 gene polymorphisms in symptomatic peripheral artery
disease. Vasc Med. 2014 May 30;19(3):175-181.
13. Spatafora C, Barresi V, Bhusainahalli VM, Di
Micco S, Musso N, Riccio R, Bifulco G, Condorelli D, Tringali C. Bio-inspired
benzo[k,l]xanthene lignans: synthesis, DNA-interaction and antiproliferative
properties. Org Biomol Chem. 2014 May 7;12(17):2686-701.
14.
Marescalco MS, Capizzi C, Condorelli DF,
Barresi V. Genome-wide analysis of
recurrent copy-number alterations and copy-neutral loss of heterozygosity in
head and neck squamous cell carcinoma. J Oral Pathol Med. 2013 Jun 10. doi:
10.1111/jop.12087.
15.
Barresi V, Bonaccorso
C, Consiglio G, Goracci L, Musso N, Musumarra G, Satriano C, Fortuna
CG.Modeling, design and synthesis of new heteroaryl ethylenes active against
the MCF-7 breast cancer cell-line. Mol
Biosyst. 2013 Jul 30.
16.
Baran I, Ganea C, Privitera S,
Scordino A, Barresi V, Musumeci F,
Mocanu MM, Condorelli DF, Ursu I, Grasso R, Gulino M, Garaiman A, Musso N,
Cirrone GA, Cuttone G. Detailed analysis of apoptosis and delayed luminescence
of human leukemia Jurkat T cells after proton irradiation and treatments with
oxidant agents and flavonoids. Oxid Med Cell Longev. 2012;2012:498914. doi:
10.1155/2012/498914.
17.
Torimura T, Ueno T, Taniguchi E,
Masuda H, Iwamoto H, Nakamura T, Inoue K, Hashimoto O, Abe M, Koga H, Barresi V, Nakashima E, Yano H, Sata M.
Interaction of endothelial progenitor cells expressing cytosine deaminase in
tumor tissues and 5-fluorocytosine administration suppresses growth of
5-fluorouracil-sensitive liver cancer in mice. Cancer Sci. 2012
Mar;103(3):542-8. doi: 10.1111/j.1349-7006.2011.02182.x.
18. Fortuna
CG, Barresi V, Bonaccorso C,
Consiglio G, Failla S, Trovato-Salinaro A, Musumarra G. Design, synthesis and
in vitro antitumour activity of new heteroaryl ethylenes. Eur J Med Chem. 2011 Nov 11.
19.
Barresi V, Romano A, Musso N, Capizzi C,
Consoli C, Martelli MP, Palumbo G, Di Raimondo F, Condorelli DF. Broad
copy neutral-loss of heterozygosity regions and rare recurring copy number
abnormalities in normal karyotype-acute myeloid leukemia genomes. Genes Chromosomes Cancer. 2010
Nov;49(11):1014-23.
20. Baran I, Ganea C, Scordino A, Musumeci
F, Barresi V, Tudisco S, Privitera
S, Grasso R, Condorelli DF, Ursu I, Baran V, Katona E, Mocanu MM, Gulino M,
Ungureanu R, Surcel M, Ursaciuc C. Effects
of Menadione, Hydrogen Peroxide, and Quercetin on Apoptosis and Delayed
Luminescence of Human Leukemia Jurkat T-Cells. Cell Biochemistry and Biophysics 2010
Dec;58(3):169-79
21.
Barresi V, Palumbo GA, Musso N, Consoli C,
Capizzi C, Meli CR, Romano A, Di Raimondo F, Condorelli DF. Clonal
selection of 11q CN-LOH and CBL gene mutation in a serially studied patient
during MDS progression to AML. Leuk Res. 2010
22. Barresi V, Ragusa A, Fichera M, Musso N, Castiglia L, Rappazzo G,
Travali S, Mattina T, Romano C, Cocchi G, Condorelli DF. Decreased expression of
GRAF1/OPHN-1-L in the X-linked alpha thalassemia mental retardation syndrome.
BMC Med Genomics. 2010 Jul 6;3:28.
23.
Fortuna CG, Barresi V, Musumarra G. Design, synthesis and biological evaluation
of trans 2-(thiophen-2-yl)vinyl heteroaromatic iodides. Bioorg
Med Chem. 2010 Jun 15;18(12):4516-23
Catania October 01, 2017
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